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drug cycling - one week on, one off
Mar 27, 2002

I recently read about a study where there was a great deal of success with patients who cycled their drugs weekly (one week on, one week off). This is attractive for two reasons: 1. I pay for a portion of my drugs and any savings is great. 2. I hate taking drugs.

Currently I am taking Viread, Epivir, and Virimune with a CD4 of 1200 and a VL less than 400.

Response from Dr. Boyle

The one week on/one week off study involved a very small number of patients on one antiretroviral regimen. It was relatively successful, and is being expanded to explore this treatment strategy further. It is premature to use this strategy at present, especially with the regimen you are on, which involves three drugs that may be one point mutation away from high-grade resistance, K65R, M184V and K103N/Y181C (among others) for Viread (tenofovir), Epivir (lamivudine) and Viramune (nevirapine), respectively.



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