Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
   
Ask the Experts About

Choosing Your MedsChoosing Your Meds
          
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  
  • Email Email
  • Glossary Glossary


Your opinion please
Mar 27, 2002

I tested positive in 1991, started therapy in 1992 and am now resistant to virtually all the NRTIs and NNRTIs. Prior to now, I have not been on any PIs. My most recent tests were VL 23,900 and CD4 285. Prior to that time, my VL has fluctuated between 500 and 7,200 during the three year period I was on my previous regimen (Videx, Sustiva, and Ziagen). (Ive never really been undetectable.) As a result of my most recent test, my doctor switched me to Viracept, 8 tablets once daily, Norvir, 2 tablets once daily, Viread, 1 tablet once daily, and Epivir, 2 tablets once daily.

I have two questions: Does this combination of drugs sound like a reasonable regimen? Is once daily dosing appropriate for these medications?

Thank you for your help. With fewer options available for me at this point, I dont feel that I can afford any more mistakes.

Response from Dr. Boyle

There is no valid evidence to support the dosing of Viracept in this fashion and due to the difficult pharmacokinetic issues involved, I would not do it. If you want to be on a once-daily PI, Agenerase (amprenavir)/Norvir (ritonavir) has been FDA approved for once-daily therapy (at 1200mg/200mg), and there are data to support Crixivan (indinavir)/Norvir, Fortovase or Invirase (Saquinavir)/Norvir and Kaletra once daily. Also, given the high-level resistance you report to the nucleosides and non-nucleosides, I would consider a regimen that includes a true double PI (e.g., Fortovase/Ritonavir at 400/400 twice daily or Fortovase/Kaletra at 1000mg/3capsules twice daily).



Previous
new therapy
Next
Alcohol and meds

  
  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS


 
Advertisement



Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement