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Once-a-day Zerit
Feb 11, 2001

I have heard that a once-a-day formulation of Zerit (Zerit-ER) will soon be available. Do you know if this drug will have any specific advantages over the twice-a-day version (which I currently use) other than being dosed once-a-day? Is it a unique formulation with special dosing requirements (evening dosing or administration with food) or the same capsule only taken once a day? Any insight you can provide would be highly appreciated.

Response from Dr. Pavia

The once-a-day formulation, as I understand it, will be taken either in the morning or the evening. The main advantage is that it will allow an all once-a-day regimen if used with another once-a-day nuke (ddI or possibly 3TC) and a once-a-day PI or non-nuke (Sustiva, Nevirapine, or the new BMS protease inhibitor). Up until now, many combinations with two drugs that can be taken only once a day have been possible, but the third drug has had to be twice a day, sort of defeating the purpose.


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