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Question about indinavir twice a day?
Nov 4, 1997

Hi thank you for a many good answers and a great help.

A friend of mine has recently started a new dosage of indinavir, now he is only taken it to times a day, but in our country (Iceland) we only get 400mg. tablets, so his doctor has told him that he has to take 1200mg although the dosage is reccomended 1000 mg. Now we are wondering if he have to drink more liquid's though the producer says that he should drink (minimum 1.5 ltr of water). I used to drink that amount when taking 800mg x3 daily but managed to get kidney problems. Could other medicin also have the same effect on our body so that we have to drink more water (3tc AZT gancyclovir etc.)? Thank´s Jon A

Response from Dr. Gallant

Using indinavir twice a day is not currently recommended, although it is being studied. In a small trial, doses of 1000 and 1200 mg twice daily looked as safe and effective as 800 mg every 8 hours, but we'll need the results of the larger trial currently in progress before we can recommend that people take that dose.

If one WERE to take such a dose, it would be just as necessary to drink lots of fluids (at least 1.5 liters).

New PI being developed by Abbott

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