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Future of HAART following resistance study
Feb 9, 2002

Dear Dr,

Do the results of the recent study showing high levels of drug resistant virus in US patients on HAART indicate that treatments will fail for many people over time?

Thanks for your thoughts.

Response from Dr. Pavia

The media reporting of the recent study from San Diego missed several important points. The study involved a group of people involved in a study of patients in long term care starting in 1995. When studied, most had been on therapy for quite a while and had lived through the era of sequential therapy. The important point is that this is not a representative picture of what virus is out there.

However, there is no question that there is more resistance over time. This will have some impact on treatment. However, it is not clear how much of an impact and whether this will influence any individual. We will have to watch carefully and use resistance testing to treat each person optimally

ATP



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