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structure treatment breaks
Feb 9, 2002

Hi,

Im researching information on Structured Treatment Breaks for a number of people on the North Coast of NSW Australia.

Ive found a couple of useful articles on the web, hot links as follows;

http://unisci.com/stories/20003/0829001.htm

http://seattlepi.nwsource.com/national/aids24.shtml

http://www.aids.org/Immunet/atn.nsf/page/a-341-01

Specifically I was looking for something described as;

Week on Week Off Therapy and research done either in Bristol (UK) or by Bristol.

I am hoping that someone in your organization might have a few clues in this area and can assist with a few links.

Any assistance you could provide would be most appreciated.

Jon Haigh.

Response from Dr. Boyle

The research you are referring to is being done at the NIH by Dybul and collagues. The last report on outcomes was at IAS last July but there may be additional reports coming soon. The reports thus far involve a very small number of patients (only 10 were enrolled) and all were on a specific regimen (2 NRTIs w/ ritonavir and indinavir), so this study can not be used to support the use of this approach in a clinical setting, but overall they showed that week on/week off therapy was safe and effective. Further studies are underway at the NIH and other centers.



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