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Dosing with kidney failure
Jan 30, 2002

My husband was diagnosed with hiv & kidney failure about april last year. We found out he is not taking half of the medications people with hiv take. And his blood work is okay for someone with hiv. Why so?

Response from Dr. Young

Thanks for your question.

Many of the HIV medications are eliminated from the body via the kidney. Hence, in persons with decreased kidney function, HIV medications (particularly the NRTIs) can be taken less frequently or with a lower dose. The particulars of dosing depend on the actual drugs prescribed and the level of kidney function (dialysis vs no dialysis, for example).

This is not true for HIV medications that are metabolized predominately by the liver, such as protease inhibitors or non-nukes-- in these cases, typical doses apply.

Hope this helps, BY



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