|Taking Crixivan Late
Feb 24, 1998
success. I have been very successful until late at taking
my Crixivan precisely on time. I've started a new job which
tends to keep my mind busy, and so on occasion (once a
week) I find myself up to an hour late taking my middle
dose of Crixivan.
I talked with my doctor today (he is a well known
researcher at University of Washington) and his
recommendation was ... not to worry! While I feel somewhat
relieved, I cannot help but wonder if his suggestion is
cautious enough. What do you think?
I've also considered moving to Viracept for a variety of
reasons. However, he recommends going to 2-a-day Crixivan
rather than switching protease inhibitors.
Is his advice sound? What is your advice?
| Response from Dr. Gallant
I'm one of the investigators on both the initial pilot study and the larger on-going trrial of twice daily Crixivan. Despite the encouraging results from the first study, we really need results from the larger study before twice-daily dosing can be recommended. The initial trial was simply not large enough or definitive enough to allow for a change in dosing-- the purpose of it was to determine the feasibility of going on to the larger more conclusive trial.
I tell people taking Crixivan to take it every 8 hours, give or take 30 minutes. I can't back that up with facts and figures, it's just based on what we know about the short half-life of the drug.
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