I have been on Crixivan, 3TC, AZT for one year with great

success. I have been very successful until late at taking

my Crixivan precisely on time. I've started a new job which

tends to keep my mind busy, and so on occasion (once a

week) I find myself up to an hour late taking my middle

dose of Crixivan.

I talked with my doctor today (he is a well known

researcher at University of Washington) and his

recommendation was ... not to worry! While I feel somewhat

relieved, I cannot help but wonder if his suggestion is

cautious enough. What do you think?

I've also considered moving to Viracept for a variety of

reasons. However, he recommends going to 2-a-day Crixivan

rather than switching protease inhibitors.

Is his advice sound? What is your advice?

I'm one of the investigators on both the initial pilot study and the larger on-going trrial of twice daily Crixivan. Despite the encouraging results from the first study, we really need results from the larger study before twice-daily dosing can be recommended. The initial trial was simply not large enough or definitive enough to allow for a change in dosing-- the purpose of it was to determine the feasibility of going on to the larger more conclusive trial.

I tell people taking Crixivan to take it every 8 hours, give or take 30 minutes. I can't back that up with facts and figures, it's just based on what we know about the short half-life of the drug.

JG