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saquinavir,ritonavir,3tc+azt, has there been a trial
Jun 15, 1998

I have been on this combination since november 97 is there any information on this combination and if so where can I find the information.

Response from Dr. Cohen

There is quite a bit on this combination, or minor variations on this theme. For example, there have been two major studies of the combination of riton/saquin presented at several of the HIV meetings over the past two years - one in the US, another in Holland. And what they both show is that the combination of the two protease inhibitors - when given to people as their first use of protease inhibitors - has been very successful at viral suppression. Which means that about 90% of those still taking the combination after one year have a viral load below 200 copies - most of them are actually below 20 copies.

In both studies - it was also seen that some people do need the addition of RT inhibitors - such as AZT/3TC - to increase the likelihood of viral suppression. Several studies - tho not all - have noted that more people have increased nausea when taking AZT and ritonavir - so there are more studies with d4T than AZT in this combination.

As these studies are still recent - most have not been formally published, but most have been presented at many meetings, and summaries of these meetings can be found on this website (see the home page for the meeting list) - and there are several newsletters that also summarize meetings where these studies have been presented. I don't know the UK versions, but in the States there are several websites that have summaries, including AIDS treatment news, Project Inform, BETA, NATAP, and others...

Hope that helps.

CC



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