Finally, theres someone who has put some sense to this drug thing. I started having lypo while off meds. I went to my doc, told himhe didnt believe me (hes a specialist in HIV research). I told him that I didnt want to have this accelerate, and that I was nervous re the PI. He put me on d4T, 3tc, and sustivia. Over the past few months the fat on my but continues to thin out, as well my legs, arms, facewell, its simply amazing how much fat (adipose tissue) other wise called subcutaneous fat, if Im correct, there is. Then theres the mitochondrial toxicity. Im now on 3tc, abacavir, and sustiviaIve read something about 3tc re mitochondrial, I thinkabacavir to something else. This may sound weird, but I can actually feel lypoI feel a sensation, like a little pinch, then that space is looser- like on my lips. This may sound weird to you, but trust me I respond really to medsmy viral load went from 76,000- 682 in 3 weeks. Im simply terrified about this fat thing. It may put you into an awkward position, but what would you do, if you were me- hypothetical, I knowbut in the end so much of this may simply be academic in the end. Please help- really,

Sincerely,

Michael (Pinocchio)

Any and I repeat ANY antiretroviral regimen can be associated with lipodystrophy. The fat wasting you are experiencing may be more likely with nucleosides than with nonnucleosides or PIs. We do not know how to reverse it. If your treatment history and your current viral load/CD4 are compatible you might try a treatment interruption. BUT I cannot give you specific advise in this forum. Talk to your Doc. AF