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Lipodystrophy and WastingLipodystrophy and Wasting
           
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What is it about protease inhibitors anyway?
Dec 7, 2003

Since it seems like protease inhibitors are one big problem in lipodystrophy, what is it that a protease inhibitor does that is good? Also this may be naive on my part but if inhibiting protease is bad, why wouldn't fostering protease be good? Does something about protease encourage or help HIV?

Response from Dr. Moyle

Inhibiting HIV protease, a key viral enzyme drammatically reduces viral load and began the revolution in HIV therapy that has saved so many lives in the developed world. Unfortunately, some members of this drug class interact with essential human enzymes/receptors so there are some side effects. Newer protease inhibitors such as atazanavir don't seem to interact so much with human proteins so may have less side effects Regards Graeme


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