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Lipodystrophy and WastingLipodystrophy and Wasting
           
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Avoiding facial wasting.
Oct 18, 2003

I am currently taking Trizivir w/ good results(t-cells 1350 viral load undetectable). I've been positive for 10 years and began Trizivir as my 1st drug 2years ago. I do not have facial wasting but am very concerned about it in the future. I know this class of drugs is considered a major culprit. My question is: If I were to notice facial wasting what would be my best course of action to stop it?

Response from Dr. Moyle

Possibly yes. The suitability of a treatment break all depends on how low your CD4 has been in the past.If it has been <200 a break is too risky. Treatment switches are the next question...removing the thymidine analog (AZT). Replacement with tenofovir may not be a good idea as a combination of tenofovir+abacavir+3TC has recently shown poor results as inital therapy. Replacing AZT with efavirenz or atazanavir may be an option and would make the regimen once daily. On a cheerier note, it may never happen.

Regards

Graeme Moyle


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