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Lipodystrophy and WastingLipodystrophy and Wasting
          
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ziagen vs. viread to replace d4t (taken with 3TC & efavirenz)
Oct 4, 2003

Hi, I am suffering from a fat distribution problem: loss of fat in face, legs and gaining fat on upper back & neck. what do you recommend me to replace zerit with ? my VL < 50, CD4 300+ I am also HCV pos.

Response from Dr. Moyle

We are currently doing a study in the UK to compare ziagen and viread in this circumstance. If you are on first ever therapy and there is no chance of resistance to nucs then I usually go for Viread (note also recent reports of lipid improvements after this switch). For any other circumstance I go for abacavir. The presence of Hep C doesn't effect the drug choice here but may be a factor that has increased you risk of getting lipoatrophy. It is not known if it slows fat recovery after switch

Regards

Graeme Moyle


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