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Lipodystrophy and WastingLipodystrophy and Wasting
           
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cortisol drug
Sep 10, 2003

A new drug in the pipeline (still in clinical trials) is called "Anticort" (steroidogenesis inhibitor). it's supposed to suppress cortisol. some studies say hiv causes adrenal failure and therefore results in low levels of cortisol. other studies say the opposite - that hiv results in hyperactive adrenals resulting in high levels of cortisol - and this possibly responsible for the immune suppression in hiv people.

have you heard of any of this, and what are your thoughts?

Response from Dr. Moyle

Studies of people who are HIV-positive and well indicate that there are no abnormalities in the way they produce or metabolise corticosteroids. Occasionally individuals with very advanced HIV disease and with infection with cytomegalovirus develop adrenal insufficiency. This generally recovers after treatment of the HIV and CMV disease. I doubt steroid blockers are going to be of much use in the setting of HIV infection

With regards

Graeme Moyle


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