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First regimen
Feb 26, 2004
Dear Dr. Moyle,
I am very concered about lipodystrophy. Could you please give an advice what would be the best first regimen to avoid this condition. What are the medications that are known to cause lipodystrophy.
Thank you very much in advance for your kind respond.
Peter
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Response from Dr. Moyle

Dear Peter
Regimens which appear to be least associated with fat loss in randomised comparative clinical trials are
tenofovir/3TC/Efavirenz
abacavir/3TC/efavirenz
ddI/FTC/Efavirenz
It is reasonable to consider that FTC and 3TC are interchangeable and efavirenz and nevirapine interchangeable from this point of view. Limited data indicate that atazanavir may also be OK if NNRTIs are not well tolerated.
Combinations including d4T and a protease inhibitor appear most associated.
I hope this helps
regards
Graeme Moyle
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