Please Note: Due to volume considerations, not all questions can be answered. Questions most likely to be answered will be those of general interest to a broad group of visitors to this forum. Questions pertaining to a specific case; requests for diagnosis, medical advice, or second opinion; or requests for opinions about untested alternative therapies will generally not be answered.
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Nucleomaxx & lipoatrophy
Mar 22, 2004
Hello Doctor,
Is there any evidence that Mitocnol(Nucleomaxx)is helpful in reversing lipoatrohy? Are there currently any studies looking into this or planned for uridine? I am interested in trying the supplement, but it is quite pricey when you consider that it's effects are only known in vitro.Many thanks in advance.
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Response from Dr. Moyle
Dr Ulrich Walker from Frieberg in Germany has demonstrated that uridine rescues cellls from mitochondrial toxicity of NRTIs. I believe he has a 'use patent' for this and is planning some pilot trials and potentially larger trials. The areas of interest include preventing lactic acidosis, treating neuropathy and treating/preventing lipodystrophy. The right doses have not been established and there is not evidence that it will work in humans. My thought is that is is best to wait until the risk/benefit of the supplement is established through well conducted trials
regards
graeme moyle
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