Ethnicity and metabolism effect on HIV progression?
Nov 25, 2001
I am 40 years old, African-American male,HIV+ Cd 375 and Vl 32,000 diagnoised two months ago, most likely contracted disease two years ago. This seems as though the virus has developed quickly? My concern is the progression of the HIV in African American males or others who have high metabolisms. I am 6'3" and weight 185lb I have been always been slim, but I have noticed that it is hard to maintain my weight. What effects the rate of disease progression? What is known about the impact of one's ethnicity and metabolism effect HIV progression and treatment?
p.s. My body temperature seem to be very high, is this a symptom of HIV progression?
Response from Dr. Holodniy
There is no data to suggest that ethnicity or race affects one's response to HIV treatment. There have been a few retrospective studies looking at whether ethnicity affects HIV disease progression. the data are inconclusive. Some studies have determined there is no difference. One recent study claims that AA men may have slower CD4 declines than whites. There is older data indicating increased development of AIDS, but these studies may be confounded by variables such as access to care and meds, etc. There are clearly genetic differences, which could affect the immune systems ability to contain HIV infection, or affect metabolism, but I don't think these variables have been studied sufficiently to be conclusive. MH
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