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Switching regimen
Sep 11, 2000

Hi Doc,

I was infected on 1/00 due to condom failure with initial VL 41,000 and CD4 320. Went on Viracept/Ziagen/Epivir (PI and 2 NARTIs) on 3/00 and finally achieved undetectable 8/00 with minimal side effects. However, have some hair loss and afraid of possible lipodystrophy and would like to switch to Viramune/Ziagen/Zerit (NNRTI and 2 NARTIs). 2nd option is to switch to Viracept/Ziagen/Zerit (PI and 2 NARTIs).

Would like your opinion before seeing my doctor next week. Thanks much!

Response from Dr. Holodniy

If you are going to make a change, doing it when your viral load is undetectable is the time to do it. You don't indicate whether you are having any cholesterol or triglyceride problems now. I am not sure I would recommend a change unless you truly had lipodystrophic changes or blood lipid problems now.

MH



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