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Non-infectious HIV

Sep 18, 2000

Dr. Holodniy,

I have read that 99.8% of HIV RNA is non infectious.If this is so, then non-infectious HIV is the source of RNA and proteins (including protease) from which the genetics and other characteristics of HIV are derived. This strikes me as problematical. Since non-infectious viruses are meaningless clinically, the data derived from them would be likewise. What is the significance of the non-infectious HIV?

Response from Dr. Holodniy

You maybe correct to a point. We however know that people with a viral load of 100,000 progress more quickly than people with a viral load of 1,000. Even if 98% of the virus is defective, the actual number derived from the viral load test has been validated to provide us with useful number line from which to gauge prognosis and therapy response.


should i take it
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