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Viral load and vaccinations.
Sep 21, 1998

I have read that viral level usually increases after vaccinations. Does it remain at an elevated level? Would yearly flu vaccinations be recommended? What about hepatitis vaccinations (esp if person is at risk for hep, but is still neg)? Does current cd4+ count have an influence in this? Thanks for any answers!

Response from Dr. Holodniy

In those patients in which it has been studied, viral load levels have only been transiently increased and then return to baseline. These increases are blunted or nonexistent in people with low viral loads, or those on effective antiretroviral therapy. The vaccinations you list are therefore recommended. It is unclear whether CD4 count alone affects this. It is related to the baseline viral load, the number of infected CD4 cells, and the number of infected CD4 cells that are actively producing virus at the time of the vaccination. MH



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