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viral load sill low skipping meds?
Sep 28, 1998

the person i mentioned was diagnosed with aids in 97 at that time the vload was 428 go figure,well he has been skipping doses here and there viracept,epivir,zerit the dr said he had this since 84 well he went back for more blood last week and the vload is still undectable i thought even messing around a little bit with the meds the vload would soar so what accounts for this i am very confused?all the other blood work was normal,the dr said he has a unuasual strain that the body is fighting need help ????????

Response from Dr. Holodniy

Given that this person was infected in 1984 and thus has been positive for 15 years, puts them in a special category of long term survivors. Many of these people have very low viral loads to begin with, without therapy. Thus, they have a better immune system or a less virulent viral strain that accounts for their longevity when compared to other infected people. It is unclear what the natural history of these people will be, or whether antiviral therapy is necessary for them. You are correct in general about patients though. If they have higher rates of replication to begin with and stop therapy, their viral loads will rebound. This may not be the case in these long term survivors with very, very low levels of replication to begin with. MH



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