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DNA PCR and Early Treatment Before HIV Seroconversion

Jan 3, 2000

Dear Dr. Holodniy:

Given the recent FDA approval of the Qualitative DNA PCR test for HIV diagnosis and also given the new research by Dr. Franco Lori who states that the "time before complete seroconversion might provide an imprtant window for therapeutic intervention to prevent irreversible immune damamge" (J Infect Dis 1999; 180:1827-1832), do you think that it is still a defensible position to recommend only an antibody test for HIV Diagnosis for those that might know the exact date of possible exposure?

Thanks for the great work you do on this site!

Happy New Year !

Response from Dr. Holodniy

Tell it to the FDA. How many patients would truly be identified during this time period to potentially benefit from such early intervention. The controlled studies still need to be done. MH

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