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clinical significance of reductions in HIV susceptibility

Oct 5, 1999

What is the clinical significance of the reported fold changes in HIV susceptibility to various antiretroviral agents in response to HIV codon mutations? Can a drug that HIV has, for example, a 5-fold reduction in susceptibilty to still be clinically effective?

Response from Dr. Holodniy

Indeed it may, combined with other agents which have equal or greater potency and/or lack of resistance. In addition, certain mutations which confer resistance (genotypic and phenotypic) to one agent, may enhance the activity of other agents. For instance a codon 184 mutation confering high level resistance to 3TC, can rescue back activity of AZT when AZT resistance is present. MH

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