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Mixed Strains

Aug 3, 1998

Dear Doctor:

From a recent question, I understand that mixed strain, or "recombinant," HIV is identified through genetic sequencing. However, how were these patients known to be infected with HIV in the first place? In other words, did conventional antibody and PCR tests pick up the infection initially, which later was determined through genetic sequencing to be a recombinant strain? Thank you.

Response from Dr. Holodniy

Yes the ELISA type antibody tests were positive. MH

strains in Thailand
Negative ELISA and PCR, But Still Infected?

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