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Stem cell replacement transfusion
Nov 18, 1998

What is the new therapy for advance AIDS patients called stem cell replacement? I can't find any current research on this subject...Thanks, Lee

Response from Dr. Holodniy

Not exactly sure what you are referring to. Stem cells are the precusor or early cells in the bone marrow that give rise to to red and white blood cells (including T cells). One thought would be to harvest some of these cells from the blood, grow more in culture, and give them back to a patient in the hopes of making more T cells. Another approach is to get stem cells from the blood and using gene therapy, insert a piece of HIV into them, making them immune from HIV infection. Infuse these altered stem cells back into a person which would then theoretically give rise to blood cells (including T cells) which would never become infected with HIV. This approach works in the test tube and in a monkey model. I am not sure of what people data there is yet. MH



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