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DNA PCR vs RNA PCR?
Mar 25, 1999

Dear Dr. Holodniy: one of your recently answered message prompted me to ask this question:

Is it possible that a RNA PCR (measures viruses inside plasma)gives Negative result; while DNA PCR (measures viruses inside cells) gives Positive result? At least, do you have any patients with this situation, or have you heard something like this???

Thank you.

Response from Dr. Holodniy

Not during acute infection, if that is what you are asking. A situation like this would commonly occur in HIV infected people who are receiving therapy in whom we would see undetectable plasma viral loads, but still have a positive DNA PCR from their blood cells. MH



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