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Brain neurons
Apr 16, 1999

I read where even if the virus were eradicated from the blood & lymph nodes, it would remain in the brain neurons. Would this allow for reemmergence if drugs were stopped ? Is it replicating in the brain or is it latent ?

Response from Dr. Holodniy

It's replicating in and around the brain. It's hard to know about HIV replication within neurons. Brain biopsies are hard to come by. We do know that infectious virus and viral load can be measured in the spinal fluid. We also know that T cells and macrophages (cells known to be HIV infected) or occur in the brain. We know that when viral load levels decline in the blood, they fall in the spinal fluid as well. The same would probably be true when stopping drugs (ie goes up in the blood, although not studied in spinal fluid). MH



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