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HOW LONG TO LIVE WITH CURRENT RESISTANCE
Jul 29, 1999

DEAR MARK, I AM RESISTANT TO NEARLY ALL DRUGS AVAILABLE. DO YOU SEE ANY HOPE FOR ME TO SURVIVE MORE THAN A FEW DECADES STILL? I AM RECENTLY DIAGNOSED WITH EXPOSURE IN JANUARY OF THIS YEAR. VL = 30,000, T-CELLS ARE 600. THINKING OF INTERLEUKIN 2 TO RAISE T-CELLS AND TO ACTIVATE HIV IN LYMPH NODES AND OTHER RESTING AREAS IF I CAN ACHIEVE A LOW OR UNDETECTABLE VL. ANY THOUGHTS OF IL2 OR ANY NEW DRUGS THAT WILL BE AVAILABLE WITHIN A YEAR SO I CAN GET STARTED? CAN YOU GIVE ME A LIST OF DRUGS TO WATCH FOR SO THAT I CAN PATIENTLY WAIT TO GO WITH A COMBO OF NEW DRUGS INSTEAD OF WASTING THEM ONE BY ONE AS SOON AS THEY ARE AVAILABLE. MY DOCTOR IS A PAIN AND DOESN'T GIVE ME ANY ADVICE OR GOOD GAMEPLANS. FROM DESPERATE AND DYING

Response from Dr. Holodniy

You might be desperate, but certainly not dying. Your CD4 count is pretty good. IL-2 is a good idea, but only in the presence of a good antiretroviral regimen. Other drugs like second generation protease inhibitors (ABT-378), fusion inhibitors (T-20), metabolic inhibitors (HE2000), gene therapy, to name a few are here. I think you can wait on the sidelines for a bit (given your high CD4 count), or dive into some of the clinical trials with these other agents. MH



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