resistance to stavudine
Sep 27, 1999
Is there any data that explains why some patients experience clinical failure on a regimen containing stavudine if there are no clinically observed codon mutations linked to stavudine resistance?
Response from Dr. Holodniy
Good question and hard to get an answer. A couple of points though. Although we can't seem to find the mutation we believe causes d4T resistance in the test tube in people, we see the cases you describe. This may be related to other mutations that affect d4T activity (like AZT related mutations), novel nucleoside analogue class mutations (meaning it takes out all those drugs: AZT, d4T, etc), or cellular metabolic issues. In the latter case, some people have found that giving d4T after AZT was less effective than if d4T was given first. This may relate to changes in cell metabolism induced by AZT that renders d4T not as effective. MH
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Itchy Rash After Giving Oral Sex Does It Mean I Have HIV
- Itchy Vagina After Having Sex During Period Sign Of HIV AIDS
- Rash After Unprotected Vaginal Sex Worried I Have HIV
- Can You Get Genital Warts From Sharing Razors Or Drinks?
- Can You Get Genital Warts Just From Touching?
- Accidental Intake Of A Double Dose Of HIV Medication
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.