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thymidine associated mutations

Oct 5, 1999

Are there any mutations in HIV RT which confer resistance to both of the thymidine nucleoside analogue RTIs (AZT and d4T)? Is the term thymidine associated mutation (TAM) one that has meaning to HIV physicians?

Response from Dr. Holodniy

Yes there are. Although AZT specific mutations don't confer resistance to d4T, a mutation at codon 151 along with a couple of others and an insertion of two amino acids at codon 69 among some other changes, confers class resistance to the nucleoside analogues (AZT, d4T type drugs). TAM would probably not have meaning to most physicians. MH

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