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Genotypic vs. Phenotypic resistance

Nov 5, 1999

What is the difference between genotypic and phenotypic resistance testing?

Response from Dr. Holodniy

Genotyping utilizes molecular biology techniques to look at changes (mutations) in the genetic sequence of HIV that are known to confer resistance to various drugs. Phenotyping uses techniques to grow a patient's virus in a test tube in the presence of various HIV drugs at different concentrations. MH

Lack of resistance when initiated HAART- confused
slight increase in VL

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