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Viability of Protease Inhibitors
Jul 19, 1999

How are Protease Inhibitors useful in treating HIV? It seems that they would need to be in the blood before infection, or immediately upon infection to be able to work, otherwise the genetic information would already be inside the cell. What is the research being done in this direction? I but can't find much -it there a scientifically minded site I could go to?

Response from Dr. Holodniy

Studies are ongoing to look at post exposure prophylaxis (PEP) with protease inhibitors after high risk exposures. San Francisco General Hospital AIDS Program is taking the lead on this. Look back studies with AZT alone given within 4 hours of a significant healthcare worker exposure had significant benefit in preventing HIV infection. MH



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