intent-to-treat data: what does it mean?
Dec 26, 1999
Often in clinical data about HIV drugs the term 'intent-to-treat' is also given. What does 'intent-to-treat' mean and how should this data be understood relative to standard results?
Response from Dr. Holodniy
Great question. Intent-to-treat carries forward all patients who enrolled in the study, regardless of whether they finished the study or dropped out because of side effects, toxicity, or choice. This is a more rigorous way to analyze study results. On-treatment analysis only looks at the patients who completed the study, which may bias one treatment arm in favor over another. It is always important to look at study results and the number of patients who started each arm of a study and how many patients are being considered in the final analysis. These may be very different numbers. For instance if 200 patients were enrolled (100 in each of two different treatment arms) and the baseline viral load is compared to the week 24 viral load in 85 patients in arm A and 65 patients in arm B, this will have very different results then if 95 are compared in each arm as intent to treat. MH
Get Email Notifications When This Forum Updates or Subscribe With RSS
- What Will Happen If I Don't Treat Shingles?
- What To Use On Open Herpes Sores?
- What If A Person With Hpv Uses The Restroom And Does Not Wash Their Hands Can You Get It?
- What Do Herpes Mouth Sores Look Like?
- What Is The Normal Range On Herpes 2 Igg Test?
- What Are Long Term Effects For Genital Herpes?
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.