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Viral Load in body...
Aug 5, 2001

Dr. Mark,

I would like to know the viral load of various body parts. Two HIV+ persons, one <50 one 100k. The <50 is on 3 csf penetrating meds. The heart, liver, kidneys, skeletal muscles, bone marrow, lymph nodes. I'd like to know how they correlate in both patients...treated and untreated.

Thanks much!

Response from Dr. Holodniy

A great question, but unfortunately we don't have the answer. In general the viral load in spinal fluid and semen is about 10 times less than in blood plasma, and in lymph nodes it's about 10-100 times more. This is in the untreated patient. In the small numbers of people that have been studied (because you would have to get tissue samples from all these places from patients), those with viral loads of < 50 in blood plasma have the same viral load in semen and spinal fluid. In lymph nodes although the viral load is markedly reduced, there are still ample cells that are infected that are present, but not necessarily producing virus.



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