|This will answer all the questions from the worried well
Jul 29, 2001
Have you ever encountered or heard of anyone (with solid evidence)who was diagnosed with AIDS(low CD4 or opportunistic infections) but never seroconverted(not counting those rare seroreversion cases)?
| Response from Dr. Holodniy
In order to answer that question, we would have to have serial blood samples on everyone who has become infected, and then followed until AIDS develops. The reported cases of AIDS with negative antibody tests (but positive PCR tests), did not have serum available at the time of infection. Thus, the question cannot be answered. The more likely explanation is loss of B lymphocytes (which make antibodies) because of advanced HIV infection.
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