|Lymphocyte Count vs. CD4
Jul 15, 2001
In Indonesia with 210 million population, and which stretches east-west the same distance as from New York to Los Angeles, there is only one center able to measure CD4 counts. It therefore becomes difficult to determine when prophylaxis should be started.
In the "Antiretroviral Therapy in Resource-Poor Settings" guidelines developed by the WHO and International Aids Society, there is discussion on laboratory evaluation. Referring to CD4 count, it notes the 'total lymphocyte count correlates very well with CD4 cell counts, particularly in advanced HIV disease, and can be used as an indicator of immune funtion.' Unfortunately there is no information on how total lymphocyte count can actually be used.
Can you clarify how total lymphocyte count can be used to replace CD4 counts, and at what CD4 level it 'correlates very well'.
| Response from Dr. Holodniy
I suggest you contact the WHO if they are the proponents of that.
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