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plasma vs serum

Jun 30, 2001

Dr. When you explain CD4 level/cubicmm of blood, does that mean plasma or serum? Where (plasma or serum) is the CD4 (T-cell) in the blood?

What is p24 antigenemia? Does that mean p24 portion of HIV is detected in the serum or plasma?

Which portion of blood is used for HIV testings such as ELISA, PCR, or RNA viremia?

Thanks you very much in advance for your help.


Response from Dr. Holodniy

The CD4 number is expressed per ml or cubic mm of whole blood. Plasma or serum by definition are Acellular, and thus Do Not contain CD4 cells. P24 antigenemia indeed means detecting free-p24 antigen from HIV in serum or plasma. Antibody and viral load tests use plasma or serum as the medium for detection. MH

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