The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

Understanding Your LabsUnderstanding Your Labs
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  • Email Email
  • Glossary Glossary

Yo-yo viral burden results

May 1, 2000

My viral burden results have been going up and down, jumping from non-detection 4 months ago to 100, 0, 70 and 190 copies (by branched chain test). My physician sent my last 2 blood samples to retest with polymerase chain test and they both came back negative. I am very loss and worried. Should I wait for the next visit and which test should I trust? Is there a possibility of resistance?



Response from Dr. Holodniy

The low level positive results can be the result of: ongoing viral replication (regimen has lost some potency, with a possibility of resistance), intercurrent illnesses, assay variability. You didn't indicate whether your CD4 count/percentage had changed over this time. It wasn't clear whether the PCR test was an ultrasensitive (50 copy cutoff), or regular PCR viral load (400 copy cutoff). The current bDNA and ultrasensitive PCR test track fairly well. If they used a regular amplicor PCR test, it would show negative, and the bDNA positive. In any case, I wouldn't do anything yet. In these cases, I follow the trend in viral load and CD4 counts closely.


Liver Enzymes

  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint