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PCR affected by treatment
May 12, 2001

Dear Dr. Holodniy,

I realize nothing is definitive (you've taught us that), but if one was to be infected by someone who is being treated with anti-virals, would the viron/s take longer to multiple in the person who has just been infected and not on anti-virals, and would it affect the timeline for a "high confidence" PCR Qualitative reading at 30 days or greater?

Thanks so much

Response from Dr. Holodniy

It partly depends on the inoculum size. An HIV infected person who has a high viral load, is more likely to transmit the infection than someone with a low viral load. This is regardless of whether they are on treatment or not. The timing of infection relative to donor viral load has not been well studied.



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