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PCR affected by treatment

May 12, 2001

Dear Dr. Holodniy,

I realize nothing is definitive (you've taught us that), but if one was to be infected by someone who is being treated with anti-virals, would the viron/s take longer to multiple in the person who has just been infected and not on anti-virals, and would it affect the timeline for a "high confidence" PCR Qualitative reading at 30 days or greater?

Thanks so much

Response from Dr. Holodniy

It partly depends on the inoculum size. An HIV infected person who has a high viral load, is more likely to transmit the infection than someone with a low viral load. This is regardless of whether they are on treatment or not. The timing of infection relative to donor viral load has not been well studied.

ELISA and PCT 24 weeks

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