|Consistently low cd4/cd8 ratio
Feb 9, 2014
Hi; I'm a healthy 49 year old, successfully treated with Atripla and its components since my diagnosis in 2004, having been undetectable with an average CD4 count of 700-1100 at 30-33%, from my baseline at diagnosis of 290 and 20%. My concern is that my total cd4/cd8 ratio has generally been off, at last testing 43% with a ratio of .76 I realize this is not uncommon, but this signify low-level viral replication and incomplete control by Atripla and a constant state of immune-based inflammation, a condition now recognized to contribute strongly to a multitude of other disease processes?
| Response from Dr. Holodniy
Your ratio is relatively good from an HIV standpoint. Given your normal CD4 count, it is likely reduced because of an increased CD8 count, which is a natural response to HIV infection. Markedly increased CD8 counts in HIV infection have been associated with inflammatory conditions perhaps leading to increased risk of cardiovascular disease as an example. The jury is still out as published papers are conflicting about whether this condition is associated with greater chance of low level HIV replication. Unfortunately there is no good intervention strategies to change the ratio through lowering CD8 counts and therefore lowering the risk of possible other diseases.
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Blood In Drinking Glasses Is It An Exposure To Hiv
- Can Rash Appear After 3 Months Exposure?
- Chances Of Getting Hiv Through One Anal Exposure
- Do Lymph Gland Get Sore In Seroconversion?
- Does Having Gential Herpes Delay Hiv Seroconversion?
- Hiv Risk Of Blowjob After Intercourse Then Kissing
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.