Hypothetical CCR5-delta32 mutation labs
Dec 8, 2013
Dear Dr. Holodniy,
Hypothetically speaking, what would the labs of someone who had the CCR5-delta32 mutation look like after they were exposed to HIV. Would they still test positive? If so, would the labs reveal a normal CD4 count with an undetectable viral load? Or would it be like someone who just received a vaccine and it would be best to use a titer?
Thank you and happy holidays!
Response from Dr. Holodniy
We don't have controlled trials to answer such a question. Hypothetically, it is likely that the CD4 count would be normal and virus levels would be undetectable. Whether HIV could be found inside immune cells, or HIV antibody production would be evident, or cell-associated immune function specific against HIV could be measured is unknown.
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