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hepb medication

Nov 10, 2013

Dear dr.,I am a chronic hepB carrier, and have known it since two and half years ago. My doctor prescribed baraclude 0.5mg and I have been taking for the past two and half years. My recent lab results are as follows hbsag quantitative-545.1 IU/ml Hbvdna- <20 IU/ml by COBAS TAQMAN method hbeag-negative


ALT-48 U/L(Cut off value 30-65)

AST-34 U/L(Cut off value 15-37)

Liver function test-Normal

Ultrasound scan: normal

Other tests such as Billurubin, ProteinTotal-Serum/Plasma, Albumin-Serum, Globulin-Serum, GGTP, ALP, AFP,Urea, Creatinine are normal. Also prothrombin time,bleeding time, clotting time are also normal. I am having diabetes which is also under control. Now I am asking certain questions reg the medication. I am 61 years old. Whether I can take peg- interferon injection along with baraclude or some other medicine to clear of the hbsag? How long shd I take the medicine to clear the hbsag? Your advice is greatly appreciated.

Response from Dr. Holodniy

Your question is a good one and very difficult to answer. Although you have cleared the HBV DNA from your blood, you still have evidence of HBV infection because of the positive HBsAg test. Some people will ultimately clear the HBVsAg as well, and others will not. We don't have a good test to know who will or will not clear the antigen. Some people must remain on HBV treatment for years because of persistent antigen levels. Adding additional drugs helps in some but not all cases.

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