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ProviralDNA PCR test and hiv mutation

Sep 29, 2013

Thanks for answering my questions.This is a follow up question to the answer.Doctor as you have said that as the hiv mutates its DNA structure changes then will the Same DNA PCR test able to detect the virus?Also after the asymptomatic stage of infection say 10 years,symptoms reappar in third stage.Is it due to lowering of the CD4 count or due to the presence of the hiv.(If CD4 cell count is normal and on the higher side of the normal range then still the symptoms related to hiv will appear?Please answer.

Response from Dr. Holodniy

The DNA test will detect virus, as the area of the HIV viral sequence that is used for the test is in a highly conserved area, which is not as prone to mutations. I am not sure what you mean by third stage. Symptoms in general are much less likely, although can certainly be present in people with HIV infection and normal CD4 counts.

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