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Truvada + Hypophospahemia

May 18, 2013

Dear Doctor,

I have been on Truvada and Raltegravir for 2.5 years (positive 3.5 years). Since starting meds my VL has always been below 50 and CD4 above 600. I have no tolerance issues or obvious side effects. I do not drink or use drugs. However in the last 6 months my Phosphate levels have dropped to 0.62 - 0.64 (normal 0.75) and ALT had gone up and is now 52. Do I need to be concerned re: this and do I need to consider switching meds? Thank you in advance.

Response from Dr. Holodniy

I would need to see some more kidney function numbers before making any decisions about switching meds. At a minimum, a urinanalysis, blood creatinine, blood urea nitrogen (BUN), and from these an estimated glomerular filtration rate. Your doctor should know about this and the effects of tenofovir (in truvada) on kidney function.

Is mararviroc safe?
My titer went up to 1:2

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