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Imiquimod use to prevent high grade dysplasia turning to cancer?

Apr 14, 2013

I have had annual anal paps since 2008, with only low grade dysplasia. In December 2012 I had HRA and they found areas of high grade dysplasia. I had a repeat pap in March 2013 and there was no more dysplasia. I remember hearing about a study out of England a few years back in which a smalll number of patients were given imiquimod (Aldera cream) to prevent dysplasia/cancer. I really do not want to get anal cancer after 26 years of HIV/AIDS. My viral load has been in check for 10 years, CD4's have been in the 100-200 range since 1983, never above 250 in the last 20 years. Just wondering if there any thoughts on off label use of imiquimod to prevent further dysplasia in people with low CD4's?

Response from Dr. Holodniy

There have not been any large enough studies that I am aware of that have demonstrated a benefit of using imiquimod as a prevention strategy.

Rash after Atripla & after Reyataz+Retonavir+Truvada
HBsAg result

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