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32% CD4 Drop

Apr 14, 2013

Hi Dr - Prior to my most recent visit my CD4 was 455 and for the for the past 2 years had not dropped below 414. However, my latest bloods came in at 309 (a drop of about 32%) I recall having a cold around the time l had my bloods done and was wondering if this could have had an effect on the drop. Even if it could have, a drop this size seems big to me? - My Dr is great and she is not concerned about this drop as my VL remains undetectable however, l am... (PS Not sure if its relevant but l have been taking Atripa for the past couple of years)

Thanks to all of the great advice you and colleagues give us.

Response from Dr. Holodniy

In general, I would agree with your doctors's assessment, given the undetectable viral load. The CD4 count can vary significantly because of time of day, stress, other ongoing medical conditions or infections, after immunizations, different laboratories or assays, among other reasons. Another number to follow is the CD4%, which is usually a more stable number over time. I suspect your CD4% has not changed significantly.

understanding hcv/rna serum results
dr you just answered a question on estimating cd4 counts

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