When looking at risk factors associated with aging and minimizing these by changing meds, what would be the issues & risks - currently on combivir & Indinivir, in my early 50's, undetectable Vload but the Indinivir significantly exaggerating LDL / HDL imbalance (high cholesterol requiring statin treatment - no drug interactions). There is a family history of significant cardio vascular disease plus severe haemophilia B (not really a concern with this question). So, on balance, what are the arguments to change or not to change ... and if I did change and there were issues of significance, can I go back with no risk. The current meds also push Billirubin to high levels - Although this appears not to be a concern and some people live with this as a condition - what are the long term issues associated, thank you.

Some would say if it ain't broke dont' fix it. Many HIV meds will result in or exacerbate ongoing lipid abnormalities. On the other hand, you could switch to other once-daily, one pill combinations like Atripla or Stribild, that might have less lipid issues and be more convenient than what you are taking now. You could always go back if these other regimens don't work out for you.