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Elevated CD8 cells 7 concerned

Dec 23, 2012

Greetings, I have been positive for approx. 20 years (diagnosed 1993), and very med adherant having gone through 4 different regimens over the years. Currently on Atripla. I am an HIV Educator that has worked in the field for over 16 years basically providing various types of case mgmt. Current T-cells are 916 as of Nov 21, 2012, w/an undetectable VL that remains consistent. I noticed during my last labs from Nov 21, 2012 that my CD8 cells are quite elevated/high (1321)according to the acceptable ranges (300-700). What could be the reason for this and should I be concerned? Just noticed this today reviewing my lab reports and will f/u with my medical provider regarding this issue. Thank you in advance for your consideration in this matter.

Response from Dr. Holodniy

I would not be concerned. In general, HIV infection results in an increase in CD8 count/response, as CD8 cells are the major subpopulation associated with fighting the infection. So many people with HIV infection have elevated CD8 counts and percent. On the other hand, very high CD8 counts that are activated (only measurable in research labs) can result in increased inflammation that has its own consequences. But this is unlikely given your count.

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