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High CD4% yet average or low CD4 count?
Mar 25, 2012

Hiya- When I was diagnosed poz six years ago, I had a CD4 at 250 but CD4% at 32. Since then, I've had great reaction to my meds and I've peaked at CD4 790 (but back to 550 recently). However, my CD4% keeps climbing. I'm at CD4%=49 now. My doc was puzzled and never could give me a good answer. I'm curious why my percentage would remain oddly high even with a lower CD4 count.

Would a high CD4% be indicative of a low CD8 count for which I should be worried? I've searched around on the net and haven't really found any clarification on this. Thanks!! D

Response from Dr. Holodniy

Not sure I can give you a good explanation, but we certainly see this. You don't indicate what your CD8 count/percent has been or is now. Although an increase in CD8 count is usually what is seen with HIV infection, we are now understanding more that in many people too many CD8 cells is not a good thing. So normalization of counts/percent may be a good thing with a normal CD4 percent.



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