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Reactivation of viremia after 36 weeks under interferon theraby
Mar 11, 2012

I am HCV patient,receiving combined therapy with pegylated Interferon and Ribavarine for 37 weeks till now.Since the 9th week, the HCV RNA showed undectable viremia . But last week(the 36th week), my PCR was positive for the first time after initiation of treatment.Low viremia only 190 International unit. Dose this mean Relapse? Should I stop Interferon?

Response from Dr. Holodniy

It could mean relapse. I would not stop treatment at this point. Given your previously consistent undetectable viral loads, you would be expected to have a high chance of long term response. You don't indicate what genotype HCV you have, or whether you have HIV infection as well. These issues among others could affect treatment response. On the other hand, if this turns out to be relapse, and if you have genotype 1 HCV, an HCV protease inhibitor could be considered. The next HCV viral load test should help determine where you are.



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